Profile – Dr Yogeshwar (Yogesh) Makanji

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Dr Yogeshwar (Yogesh) Makanji

yogesh_makanji

Research Group Head, Ovarian Microenvironment Group
NHMRC CJ Martin Research Fellow

email: yogeshwar.makanji@hudson.org.au

Prior to his appointment as Head of the Ovarian Microenvironment Group in November 2014, Dr Yogeshwar Makanji most recently held the position of Visiting Research Scholar, at the Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

After finishing his Honours degree in inhibin biology at RMIT University in 2002, Dr Makanji then completed his PhD entitled ‘The biological characterisation of inhibin A and inhibin B’ at Monash University, 2009. In 2010, Dr Makanji received an NHMRC CJ Martin Fellowship and joined Professor Teresa Woodruff’s Oncofertility Consortium Laboratory at Northwestern University, USA, 2011-2013. During his overseas fellowship, Dr Makanji gained expertise in three-dimensional ex vivo ovarian culture systems. In addition, he developed systems to study the role of oxygen tension and related carbohydrate metabolism.

His current research focuses on defining the roles of oxygen tension during early follicle development, the stage-dependent roles of TGF-β superfamily members (activins, inhibins, anti-mullerian hormone, growth and differentiation factor-9, and bone morphogenetic protein-15) and the underlying energy metabolism required for follicle maturation. The overall aim of his research is to recreate the ovarian microenvironment using three-dimensional ex vivo culture systems. Outcomes from his research would result in long-term ovarian cultures of human primordial follicles for fertility restoration in cancer survivors with cryopreserved ovarian tissue.

Dr Makanji is a global member of the Oncofertility Consortium, editorial board member of Repropedia, a reproductive lexicon, and serves on the US Endocrine Society’s Annual Meeting Steering Committee.

Research Project